Animal cell culture processes

The course teaches the simulation based scale-up and optimization of animal cell bioreactors. It first describes the kinetic analysis and modeling simulation at the laboratory. Then, at the industrial scale, the optimization of the bioreactor operational mode and variables. The methodology is learned through a R&D project on monoclonal antibody production.

  

Design and analyze experiments to determine the kinetics of animal cell cultures 

• Construct simulation models of cell cultures in batch, fed-batch and perfusion operations 

• Use process simulators to scale up, design and optimize cellular bioreactors

• How to control dissolved oxygen and carbon dioxide, medium pH and proteins qualities ?

• Design downstream processes for proteins purifications 

• Evaluate the investment and operational cost of animal cell culture processes