BioProcess Digital Courses
Animal cell culture processes
Learn how to scale-up and optimize animal cell bioreactors
The course teaches the simulation based scale-up and optimization of animal cell bioreactors. It first describes the kinetic analysis and modeling simulation at the laboratory. Then, at the industrial scale, the optimization of the bioreactor operational mode and variables. The methodology is learned through a R&D project on monoclonal antibody production.
WHAT YOU'LL LEARN ?
Design and analyze experiments to determine the kinetics of animal cell cultures
Construct simulation models of cell cultures in batch, fed-batch and perfusion operations
Use process simulators to scale up, design and optimize cellular bioreactors
How to control dissolved oxygen and carbon dioxide, medium pH and proteins qualities ?
Design downstream processes for proteins purifications
Evaluate the investment and operational cost of animal cell culture processes
VIRTUAL R&D PROJECT
Design and optimal operation of a monoclonal antibody production process
Kinetic analysis of CHO cells growth, metabolism and antibodies production
Simulation model of CHO cells culture bioreactor
Optimal operation of batch, continuous, fed-batch and perfusion bioreactors for mAbs production
Sizing and cost evaluation of the mAbs production and purification process