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BioProcess Digital Courses

scale-up and optimize microbial fermentors

Microbial fermentation processes

Learn how to scale-up and optimize microbial fermentors  

COURSE DESCRIPTION

The course teaches the simulation based scale-up and optimization of microbial fermentors. It first describes the kinetic analysis and modeling-simulation at the laboratory. Then, at the industrial scale, the optimization of the fermentor operational mode and variables. The methodology is learned through a R&D project on glutamic acid fermentation

WHAT YOU'LL LEARN ?​​

  • Design and analyze experiments to determine the kinetics of microbial reactions

  • Construct fermentors simulation models in batch, continuous and fed-batch operations

  • Use process simulators to scale up, design and optimize microbial fermentors for highest productivity or lowest production cost

  • What are fermentors productivity limitations by microbial reaction, oxygen and heat transfers ?

COURSE SESSIONS

VIRTUAL R&D PROJECT

Design and optimal operation of a glutamic acid fermentation process

  • Kinetic analysis of Corynebacteria growth and metabolism

  • Simulation model of glutamic acid fermentation

  • Cost evaluation of glutamic acid production process

  • Optimal operation of batch, continuous and fed-batch fermentors

  • Fermentation intensification by oxygen-enriched air and membrane perfusion

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